HALT-C Existing Ancillary Studies

There are currently 33 ancillary studies being conducted in conjunction with the HALT-C Trial. Click on the links for more information about each study.

  1. Immunologic and Virologic Correlates of Liver Fibrosis
  2. Hepatic Steatosis in Chronic Hepatitis C: Risk Factors and Role in the Development of Hepatic Fibrosis
  3. Serum Fibrosis Markers in Chronic Hepatitis C
  4. Cognitive Effects of Long-Term Pegylated Interferon in Patients with Chronic Hepatitis C
  5. Pre-Study Serial Histology as a Predictor of Response to Continuous Therapy During the HALT-C Trial
  6. Quantitative Assessment of Hepatic Function in Chronic Hepatitis C
  7. Risk Factors for Progression of Liver Disease in Chronic Hepatitis C
  8. Iron and HFE Mutations in Chronic Hepatitis C
  9. Bayer Versant bDNA 3.0 Quantification and TMA Detection of HCV RNA for the HALT-C Trial
  10. Measurement of Serum Des-γ-Carboxy Prothrombin (DCP) for Early Detection of Hepatocellular Carcinoma (HCC) in Patients with Chronic Hepatitis C Virus (HCV) Infection
  11. Clinical Utilities of AFP-L3 Determination in Early Recognition, Diagnosis and Prognosis of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C
  12. Influence of Host Genes on the Course of Chronic Hepatitis C
  13. Analysis of Gene Expression in HCV-Infected Liver: Identification of Genes Associated with Responsiveness to Pegylated Interferon and Ribavirin therapy
  14. Genetic Predictors of Depressive Symptoms Among Patients Treated With Interferon-α
  15. Genetic Polymorphisms Associated with Non-Response to Treatment of Chronic HCV Infection
  16. Effects of Interferon on Portal Hypertension Ancillary Study
  17. HCV RNA Testing in HALT-C Sustained Virologic Responders
  18. The Impact of Peginterferon Alfa-2a Maintenance Therapy On Portal Hypertension in Patients With Chronic Hepatitis C Virus Infection and Advanced Fibrosis and Cirrhosis Enrolled in the HALT-C Trial
  19. Quasispecies Analysis of HCV Breakthroughs Occurring During the HALT-C Trial Lead-In Treatment Phase
  20. Role of HCV sequence variation in liver pathology
  21. Hepatitis C Virus Quasispecies in the Resistance to Antiviral Therapy
  22. Association of SVR with KIR and HLA Class I genotypes
  23. Suitability of OCT liver samples for Gene Expression Analysis
  24. Effects of long-term interferon-alfa therapy on maintenance of T lymphocyte replicative potential
  25. Long-term Follow-up of HALT-C Sustained Virologic Responders
  26. Validation of Cirrhosis Risk Score in Patients with Chronic Hepatitis C
  27. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in the HALT-C cohort
  28. Application of Novel Organ-Specific Serum Protein Biomarker Candidates to Diagnose Hepatic Fibrosis in Hepatitis C Patients in HALT-C Trial
  29. Analysis of GP73 and fucosylated kininogen in the HALT-C - patient cohort
  30. N-glycans for the detection of hepatocellular carcinoma
  31. Genome-wide Association Study of Depression and Suicidal Ideation Emerging during Interferon Treatment Investigators
  32. Analysis of keratin genetic variants and Mallory-Denk bodies in patients with chronic hepatitis C
  33. The Association of Serum Vitamin D Levels and Progression of Hepatic Fibrosis
  34. Statistical methods for prospective evaluation of biomarkers
  35. Utility of the SCCA-lgM biomarker for HCV-related HCC
  36. Occult HBV Infection and HCC in HALT-C Patients